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Cytokine production by Kupffer cells, which is regulated by NFκB, causes severe liver injury in endotoxin syndrome. NFκB decoy has been reported to inhibit NFκB-mediated transcription. The purpose of this study is to inhibit LPS-induced cytokine production by Kupffer cell-targeted delivery of NFκB decoy using fucosylated cationic liposomes (Fuc-liposomes). Cholesten-5-yloxy-N-{4-[(1-imino-2-l-thiofucosyl-ethyl)-amino]...