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COMMENTARY ON: TGR5-mediated bile acid sensing controls glucose homeostasis.Thomas C, Gioiello A, Noriega L, Strehle A, Oury J, Rizzo G, Macchiarulo A, Yamamoto H, Mataki C, Pruzanski M, Pellicciari R, Auwerx J, Schoonjans K. Cell Metab 2009;10(3):167–177.Copyright (2009), with permission from Elsevier.Abstract: TGR5 is a G protein-coupled receptor expressed in brown adipose tissue and muscle, where...
Ileal bile acid-binding protein (I-BABP) is a 14 kDa cytosolic protein which binds bile acids with a high affinity. It is thought to be implicated in the enterohepatic circulation of bile acids and, hence, in cholesterol homeostasis. Using a combination of in vivo and in vitro experiments, we have recently shown that I-BABP gene expression can be indirectly up-regulated by cholesterol through the...
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