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Electrophysiological devices are connected to the body through electrodes. In some applications, such as nerve stimulation, it is needed to minimally pierce the skin and reach the underneath layers to bypass the impedance of the first layer called stratum corneum. In this study, we have designed and fabricated surface microneedle electrodes for applications such as electrical peripheral nerve stimulation...
Local field potentials (LFPs) recorded through electrodes implanted in patients with Parkinson's disease (PD) for deep brain stimulation (DBS) provided physiological information about the human basal ganglia. However, LFPs were always recorded 2–7 days after electrode implantation (“acute” condition). Because changes in the tissue surrounding the electrode occur after DBS surgery and could be relevant...
Electrical stimulation of neural tissue requires charge injection into the biological environment. This is achieved through both Faradaic and non-Faradaic reactions at the electrode/tissue interface. Some Faradaic reactions have the potential to dramatically alter pH levels, leading to tissue damage. The present study looked to investigate the effects of stimulus induced pH changes for a variety of...
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