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Mutations and copy number variants affecting DYRK1A gene encoding the dual-specificity tyrosine phosphorylation-regulated kinase 1A are among the most frequent genetic causes of neurodevelopmental disorders including autism spectrum disorder (ASD) associated with microcephaly, febrile seizures and severe speech acquisition delay. Here we developed a mouse model harboring a frame-shift mutation in...
Dicarboxylic acids are an important source of information about metabolism and potential physiopathological alterations in children with autism spectrum disorders (ASDs). We measured the concentration between dicarboxylic adipic and suberic acids in children with an ASD and typically-developing (TD) children and analyzed any relationships between the severity of the core symptoms of ASDs and other...
Software project management involves coordinating various aspects of a project in order to bring forth a positive result. There have been increasing challenges faced by project managers. The major challenges of project management include unrealistic deadlines, communication deficit, uncertain dependencies, failure to manage risk, not well-defined vision and goals, and invisibility of the final product...
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