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Ion channels are molecular entities that are responsible for electrical signal generation in nerve, muscle and other cells. The paper discusses the use of tangent hyperbolic functions (TANH) in the modelling of the Big Conductance Potassium (BK) ion channel, especially for the smooth muscle of the urinary bladder. Ion channels are often modelled using the Hodgkin-Huxley formalism, in which equations...
The aim of this study was to compare the mode of action of the commonly used BK inhibitor paxilline with that of the more recently discovered lolitrem B. Similarities and differences in characteristics of inhibition between the two compounds were investigated. We have previously shown that lolitrem B does not affect the BK channel G–V, in contrast to the rightward shift produced by paxilline. These...
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