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A new type of derivatizing agent 2-chloroethylnitrosourea (CENU) has been developed for biogenic amine determination. The compounds of this family of reagents have a modular structure which allows modification in the type of detection. The derivatization reaction takes 15 min at about 75°C and is brought about by mixing a basic aqueous solution of an amine (histamine, cadaverine, putrescine) with...