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Background
Imaging tools that allow quantification of Parkinson's disease (PD) progression could facilitate the development of disease‐modifying therapies. Cross‐sectional studies have shown presynaptic terminal damage in PD patients, but longitudinal data are limited.
Objectives
The aim of this study was to longitudinally assess loss of presynaptic terminals in general and dopaminergic presynaptic...
Background
It has been hypothesized that the pathology of Parkinson's disease (PD) primarily affects presynaptic terminals and spreads trans‐synaptically.
Objectives
The main objective of this study was to assess the magnitude and anatomical extent of presynaptic terminal loss across the brain in early PD. A second objective was to compare loss of presynaptic terminals and cell bodies within the...
Objective
Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that bind synaptic vesicle glycoprotein 2A (SV2A). In vitro and in vivo animal studies suggest faster brain penetration and SV2A occupancy (SO) after dosing with BRV than LEV. We evaluated human brain penetration and SO time course of BRV and LEV at therapeutically relevant doses using the SV2A positron emission tomography...
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