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The present study used Western blots and Northern slot blots to determine changes in the level of expression of GABA A receptor subunits α 1 , α 2 , and α 3 , in relation to the 'critical period' in cat visual cortex. Levels of the GABA A α 1 subunit were lowest at 1 week, increased four-fold to a maximum at 10 weeks, and declined slightly (35%) into...
Glutamate receptors have multiple roles in the central nervous system. Recent evidence suggests that the iontropic glutamate receptors are critical during brain development, particularly for corticogenesis, neuronal migration, and synaptogenesis. In this study, we examined subunit mRNA expression and binding sites of the NMDA, AMPA, and kainate receptors from gestational weeks 8-20 in human fetal...
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