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In this work, we investigate the performances of segmentation algorithms applied to micro-CT images of small animal to derive anatomical templates for guided Fluorescence Molecular Tomography. We report on the performances of Active Contours methods to retrieve the boundary surface of the specimen and the internal distribution of a fluorescent probe. The spatial information gained from this segmentation...
A hybrid imaging system for simultaneous fluorescence tomography and X-ray computed tomography (XCT) of small animals has been developed and presented. The system capitalizes on the imaging power of a 360 ??-projection free-space fluorescence tomography system, implemented within a microcomputed tomography scanner. Image acquisition is based on techniques that automatically adjust a series of imaging...
A fluorescence enhanced diffuse optical tomography algorithm taking into account the optical heterogeneities is presented. It is suitable for continuous wave acquisitions and naturally handles complex shaped object. Therefore, it allows in vivo studies of small animals injected with target-specific fluorescent probes without immersion fluid. A comparison with previous methods conducted on simulations...
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