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Gene regulatory networks are highly complex dynamical systems of biomolecular components - genes, mRNA, proteins. These components interact with each other and through those interactions determine gene expression levels, i.e., determine the rate of gene transcription to mRNA and, consequently, the rate of mRNA translation to proteins. In this paper, a particle filter with MCMC move step is employed...
Fibronectin is a protein having multiple functions. Its coordinates of structure have several function domains. We analyzed mRNA. As a result, we show tiny gene duplication is 9.9% over the whole sequence; this value is equivalent to one of the Alu Familis. Next we analyzed some another genes of Tiny Gene Duplication. As results, we found Beta-actin: 9.5 %, GAPDH : 10.5%, Profilin : 10.7%, Elastin...
A genetic regulatory network is a dynamic system to describe interactions among genes (mRNA) and its products (proteins). From the statistic thermodynamics and biochemical reaction principle, a genetic regulatory network can be described by a group of nonlinear differential equations with time delays. Stability is one of interesting properties for genetic regulatory network. Previous studies have...
We have previously shown that TGF-1 and VEGF expression are increased in the smooth muscle cell (SMC) layer of the pulmonary vessels of lambs with pulmonary hypertension secondary to increased pulmonary blood flow. Further we found that TGF-1 expression increased prior to VEGF. Due to the increased blood flow in these lambs the SMC in the pulmonary vessels are exposed to increased levels of cyclic...
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