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A systemic approach to development of process analytical technology (PAT) tools for monitoring the critical quality and performance attributes of the manufacturing process is of great importance in ensuring final product quality in the pharmaceutical industry. The aim of this study was to examine the possibilities for a visual inspection technique as a PAT tool for in-process and on-line monitoring...
The goal of this study was to validate visual imaging as a process analytical technology (PAT) tool for the understanding and on-line monitoring of pellet coating processes. An automatic imaging system was designed for on-line, in-line or at-line fast analysis of pharmaceutical pellets. A simple yet effective tool is proposed to gain additional insight into the coating process. The method is based...
An image analysis algorithm for extracting particle size distribution information from in situ images of suspended, high-aspect-ratio crystals is described. The accuracy of the algorithm is assessed using comparisons with results obtained by manually sizing the imaged crystals. The algorithm can accurately extract crystal size information from in situ images of suspended, high-aspect-ratio crystals...
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