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A detailed intracellular (IC) model describing the pharmacokinetics (PK) of gemcitabine (2',2'-difluoro-2'-deoxycytidine, dFdC) was developed and linked to a systemic plasma dFdC PK model. Based on in vivo PK, pharmacodynamic (PD) effect predictions were made using a simplified cell-cycle model (CCM). A reduced-order compartmental model describing the IC metabolism of dFdC was fit to in vitro data...
Red toon leaves have been consumed as herbal medicine and vegetable. In this study, the antioxidant and cytotoxic activities of its ethanol extract were investigated. The results showed that the extract was an effective scavenger in quenching hydroxyl radicals with IC50 of 10.57 mg/mL. A linear correlation between concentration of the extract and reducing power was observed with a coefficient of r2...
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