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β-NAD + is as abundant as ATP in neuronal cells. β-NAD + functions not only as a coenzyme but also as a substrate. β-NAD + -utilizing enzymes are involved in signal transduction. We focus on ADP-ribosyl cyclase/CD38 which synthesizes cyclic ADP-ribose (cADPR), a universal Ca 2+ mobilizer from intracellular stores, from β-NAD + . cADPR acts through activation/modulation...
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