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Obesity, currently affecting more than one third of all adults in the United States, is a complex disease with a multifactorial etiology involving genetic and environmental factors. Public health prevention programs designed to reduce the risk and occurrence of obesity and overweight commonly focuses on modifiable environments and behaviors such as diet and physical activity with varied results among...
What is known and Objective: The increasing prevalence of obesity and associated morbidity present unmet medical needs for safe and effective new drug therapies. Our aim is to review the diverse targets and compounds that are in clinical development.
Methods: Literature searches were conducted using the PUBMED database for studies published in English from January 1985 to December 2011 using combinations...
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