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Drug bioavailability is a major failing point of new pharmaceuticals i.e. drugs fail to reach their target or fail to stay there long enough for therapeutic effect. Compounding this issue, significant variability exists between patients and how they metabolize and distribute a drug. We present WebPK, a web-based tool for simulation of custom pharmacokinetic models. Model parameters can be entered...
Cardiovascular diseases are one of the main reasons for morbidity and mortality in developed countries. In the paper simulation results are presented regarding the development of high blood pressure and its connection with the myocardial infarction. The goal of the work was to define the mathematical structure with which it would be possible to estimate the number of observed patients, healing costs...
Mathematical and computational tumor dynamics models can provide considerable insight into the relative importance and interdependence of related biological mechanisms. They may also suggest the existence of optimal treatment windows in the generic setting. Nevertheless, they cannot be translated into clinical practice unless they undergo a strict and thorough clinical validation and adaptation. In...
Contemporary people live in a society featured by a continuously increasing complexity. As a consequence, interdisciplinary approaches represent a must for every scientist that aims to efficiently manage a certain problem. Cancer evolution and the associated proper medication strategy is an example of such a complex problem that requires an interdisciplinary approach in order to be properly addressed...
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