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The investigation of micronuclei in mitogenic stimulated hepatocytes in vitro is a quite new area of research. Nevertheless, a relatively large database comprising more than 40 tested compounds of various classes has been generated up to now. This paper reviews the available data for the in vitro rat hepatocyte micronucleus assay, showing a sensitivity of this assay in identifying mutagens and genotoxic...
Based on a previous study with 8 chemicals (Muller et al., 1993) the applicability of the in vitro rat hepatocyte micronucleus assay was evaluated by testing a further 21 compounds of different chemical classes. The obtained results are in good agreement with the known genotoxic profiles of about 90% of the in total tested compounds. Several known mutagens and carcinogens, i.e., alkylating agents,...
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