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Estradiol has been evaluated in five independent rodent bone marrow micronucleus assays and has been found to be inactive. The dose-range evaluated extended from three daily doses of 20 μg/kg to the rat, a regimen that elicited a potent uterotrophic response from the animals, to single doses of between 10-150 mg/kg to the mouse. The mouse assays simulated and extended the conditions of test employed...
Genotoxic evaluation of estradiol, a commonly used estrogen, was undertaken using various short-term in vitro and in vivo assays. The clastogenic potential of estradiol was evident from the chromosome aberrations and sister chromatid exchanges induced by it both without and with metabolic activation in cultured human lymphocytes and also from the increased frequencies of micronuclei formation and...
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