The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Small nucleolar RNAs (snoRNAs) are mainly involved in rRNA processing and modification, including the maturation of precursor ribosomal RNAs (pre-rRNA), and methylation and pseudouridy nation of rRNA bases. These moleclules are transcripted independly, along with host gene as an intron or as polycistron, reflecting the different pathways for processing of precursor snoRNAs (pre-snoRNAs) into mature...
We present a statistical framework, MAMS-M, for determining the methylation status of hundreds of cancer related CpG sites. MAMS-M extends and adapts our previous SNP genotyping algorithm, MAMS, to methylation bead array data, exploiting the similarities in data structure between the two platforms. MAMS-M employs a multi-site, multi-array model-based clustering approach to derive initial methylation...
DNA molecules are wrapped around histone octamers to form nucleosome structures whose occupancy and histone modification states profoundly influence the gene expression. Depending on the DNA segment that a nuleosome incorporated, its histone proteins exihibit paticular modifications by added some functional chemical groups to specific amino acids. The key approach up to now to determining the DNA...
Determining the global pattern of DNA methylation, or the methylome and its variation in cells has become an area of considerable interest primarily because of its potential use as an early diagnostic biomarker for cancers. Genome survey techniques are now being used to identify heavily methylated regions on a massive scale and there is a need to correlate this data with focused biomedical information...
Heterogeneous genetic and epigenetic alterations are commonly found in human non-Hodgkin's lymphomas (NHL). One such epigenetic alteration is aberrant methylation of gene promoter-related CpG islands, where hypermethylation frequently results in transcriptional inactivation of target genes, while a decrease or loss of promoter methylation (hypomethylation) is frequently associated with transcriptional...
Identification of DNA regions that are rich in the CpG pattern is important because such segments are resistant to methylation and are typically associated with genes that are frequently switched on. In this paper, we propose a DSP based approach to detect such regions. In specific, we first derive two new Markov chain models for CpG and non-CpG regions respectively and then design a number of FIR...
Several novel microarray technology platforms to be applied to acquire both genetic and epigenetic data from biological systems have been developed. Genetic database and the related bioinformatics analytic tools are being constructed. Here, some on-going projects related to bioinformatics analysis based on the microarray technology, such as such as the high density microarray design, combinational...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.