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Tinaspora crispa and Gelam (Melaleuca sp.) honey were identified as potential anti-proliferative agents due to presence of high antioxidant activity. In this research, human breast adenocarcinoma (MCF-7), human colorectal carcinoma (HCT116), human hepatocellular carcinoma (HepG2) and adenocarcinoma human alveolar basal epithelial (A549) cell lines were treated with both extracts and further diagnosed...
Drug metabolism is an important aspect for the study of toxic effect in human being. However, the occurrence of several regulatory issues and high cost involved in experimental study on drug metabolism, restrict the study using human as a model system. Keeping this in view, in the present study, the fungus Aspergillus niser was chosen as a model organism for the study of Clemastine metabolism as it...
Studies on the twigs of Garcinia eugenifolia have led to the isolation of one xanthone 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-enyl)pyrano[3,2-b]xanthen-6(2H)-one (1) and one triterpenoid, sitosterol (2). Meanwhile, studies on the leaves of Garcinia eugenifolia provided another triterpenoid, friedelin (3). The structures of these compounds were determined by spectroscopic methods such...
This study aims to determine the antioxidant activities of traditional plants from the Lauraceae family in Sarawak. Twenty selected plants from the Lauraceae family were collected from various mixed dipterocarp forests located in the Kuching and Samarahan Districts of Sarawak. Their antioxidant activities were evaluated on the methanolic extracts using the DPPH (2,2-Diphenyl-l-picrylhydrazyl ) assay...
Phthalates are widely used in industry as solvents, additives and plasticizers. Some phthalates and their monoester metabolites are known to cause carcinogenic, toxic or endocrine-modulating effects. Chorion tissues as human early embryo are the base of organogenesis. Embryo (3-8 weeks) is sensitive period of teratogensis. With the development of industrialization, in addition to genetic factors,...
A novel method for fast determination of nicotine in hunman plasma and urine was introduced by using high performance liquid chromatography ( HPLC) coupled with ionic liquid based liquid phase microextraction (LPME) technique for sample preparation. Some effective parameters on extraction including extraction solvent, pH of donor phase, extraction time, extraction temperature and stirring speed was...
The plant Macaranga peltata (Euphorbiaceae) leaves and stem bark was tested for its in vitro antioxidant, antimicrobial and cytotoxicity activity using different methods. In vitro anti oxidant activity stem bark extract showed inhibitory concentration 50% (IC50) value of 10.13 than the leaf extract IC50 = 14.85 for DPPH assay. Standard ascorbic acid showed IC50 = 7.28. For ABTS free radical scavenging...
The present study was to investigate the protective effect of Echinacea, purpurea (E. purpurea) extract, a natural scavenger of peroxynitrite (ONOO-), on the biomolecules injury induced by ONOO- in vitro. The results showed that E. purpurea extract could prevent the ONOO--mediated damage in tyrosine nitration, low density lipoprotein (LDL) oxidation and DNA strand breaks. The ONOO- scavenging ability...
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