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Purpose
To develop an efficient MRI approach to estimate the nonwater proton fraction (f) in human brain.
Methods
We implement a brief, efficient magnetization transfer (MT) pulse that selectively saturates the magnetization of the (semi‐) solid protons, and monitor the transfer of this saturation to the water protons as a function of delay after saturation.
Results
Analysis of the transient...
PurposeMacromolecular proton fraction (MPF) mapping is a quantitative MRI method that reconstructs parametric maps of a relative amount of macromolecular protons causing the magnetization transfer (MT) effect and provides a biomarker of myelination in neural tissues. This study aimed to develop a high‐resolution whole brain MPF mapping technique using a minimal number of source images for scan time...
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