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Magnetic resonance spectroscopy (MRS) known for its non-invasive and nondestructive nature, has been applied in biomedical and clinical research to assess the biochemical and metabolic information in a living brain. However, the applicability and detection sensitivity of in vivo MRS are, in general, limited by low concentrations of most cerebral metabolites of interest. The newly advanced high/ultrahigh...
Tissue deterioration as induced by disease can be viewed as a continuous change of tissue from healthy to diseased and hence can be modeled as a non-linear manifold with completely healthy tissue at one end of the spectrum and fully abnormal tissue such as lesions, being on the other end. The ability to quantify this tissue deterioration as a continuous score of tissue abnormality will help determine...
Magnetic Resonance Spectroscopy (MRS) signals are being used for diagnosis of various brain diseases. Feature extraction of the MRS data is the most important step in analyzing the data. In this study a fully automated system is developed to analyze the MRS signals. The wavelet analysis is utilized in extracting signal features and the time-frequency representations. Consulting specialists in the...
The purpose of this study was to explore mitochondrial activities after oxygen inhalation by 31P magnetic resonance spectroscopy. Six healthy volunteers were studied using a GE 3 T scanner. A spin-echo MRS sequence was utilized with a GE service coil. TR was 2000 msec and TE 35 msec with 128 scan averages. Before 31P scan, a 1H MRS pre-scan was performed to obtain shimming values. Exact two 31P scans...
This paper investigates variable selection (VS) and classification for biomedical datasets with a small sample size and a very high input dimension. The sequential sparse Bayesian learning methods with linear bases are used as the basic VS algorithm. Selected variables are fed to the kernel-based probabilistic classifiers: Bayesian least squares support vector machines (BayLS-SVMs) and relevance vector...
The perfect shimming of 31P magnetic resonance spectroscopy (MRS) is not easy in vivo. The purpose of this study was to examine the feasibility of using 1H MRS shimming values to obtain 31P spectra in a same sequence. Both phantom and volunteer studies were carried out in this study. Phantom was a sphere filled with physiological metabolites of brain. In vivo study was performed on 4 healthy volunteers...
The perfect shimming of 31P magnetic resonance spectroscopy (MRS) is not easy in vivo. The purpose of this study was to examine the feasibility of using 1H MRS shimming values to obtain 31P spectra in a same sequence. Both phantom and volunteer studies were carried out in this study. Phantom was a sphere filled with physiological metabolites of brain. In vivo study was performed on 4 healthy volunteers...
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