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Signal processing techniques such as Fourier Transform have widely been studied and successfully applied in many different areas. Techniques such as zero-padding and windowing have been developed and found very useful to improve the outcome of the signal processing methods. Resonant Recognition Model (RRM) and Complex Resonant Recognition Model (CRRM) that are based on the discrete Fourier Transform...
We investigate a method for the detection of influenza A virus in order to reduce the risks associated with its toxicity. Our work is based on the analysis of the optical properties of a whispering gallery mode microresonator interacting with a spherical nanoparticle modeling the virion. The microresonator shows a Q-factor quite high, of the order of 6·104. Higher is the Q-factor, higher is the perturbation...
We studied the evolution of HIV-1 (Human Immunodeficiency Virus Type 1) by means of coding theory and information dynamics. More precisely, (1) we applied various artificial codes to look for the similarity between these codes and the code of HIV-1; (2) the entropic chaos degree was used to describe the evolution of HIV-1.
Resonant Recognition Method that uses discrete Fourier transform (DFT) and Electron-ion interaction potential amino acid scale (EIIP) is one of the techniques widely used for the analysis of protein sequences. However, DFT that generates complex output (imaginary and real frequency spectra) has shown to produce complementary information in other areas (e.g., ultrasound) were not taken into consideration...
A novel influenza A (H1N1) virus of swine origin emerged in the spring of 2009 and spread very rapidly among people. The severity of the disease and the number of deaths caused by a pandemic virus varies greatly and can change over time. For these reasons it becomes a challenge to study the genomic features that characterize this new virus. At the same time, the theory and methods of signal processing...
In March and April 2009, an outbreak of H1N1 influenza in Mexico led to hundreds of confirmed cases and a number of deaths. The worldwide spread of H1N1 had attracted everyone's attention and arisen an overwhelm fear. Up to now, there is still an urgent need in the solution for ending this light. In this study, a QSAR model of neuraminidase (NA) type 1 (N1) provides an access. The pharmacophore map...
Influenza A viruses are negative-strand RNA viruses. The gene of hemagglutinin (HA) protein in the virus genome is the major molecule that determines the range of hosts. Mutation of HA gene may bring infection cross species. In this paper, we studied physicochemical constraints during the variations of HA gene. Fuzzy measure and Choquet integral were used to estimate the combining effect of different...
Membrane insertion of small peptides plays important roles in antimicrobial defense, toxin actions, and viral infections. There have been experimental efforts to study this process with carefully designed synthetic peptides. Molecular dynamics simulation techniques are useful tools to study membrane insertion of peptides in atomic details to complement these experimental efforts. We developed a methodology...
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