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Inflammation is a complex response that involves interactions between multiple proteins in the human body. The interaction between inflammation and coagulation is well-recognized, but its role in the dysregulation of coagulation in xenograft recipients is not well-understood. Additionally, inflammation is known to prevent the development of T cell tolerance after transplantation.Recent evidence indicates...
BackgroundDysregulation of coagulation is considered a major barrier against successful pig organ xenotransplantation in non‐human primates. Inflammation is known to promote activation of coagulation. The role of pro‐inflammatory factors as well as the relationship between inflammation and activation of coagulation in xenograft recipients is poorly understood.
MethodsBaboons received kidney (n = 3),...
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