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A novel lectin, isolated from the basidiomycete mushroom Clitocybe nebularis and termed C. nebularis lectin (CNL), exhibits an immunostimulatory effect on the most potent antigen‐presenting cells, the dendritic cells (DCs). Treatment of human monocyte‐derived DCs with CNL in doses from 1 to 10 μg/ml resulted in a dose‐dependent induction of overall DC maturation characteristics. Exposure of DCs to...
We have studied the effect of cyclosporin A (CSA) on the expression of genes involved in the immune response in mice bearing a transgenic T cell receptor specific for the peptide 88-104 of the pigeon cytochrome c. Immunization of mice treated with CSA resulted in the blockade of the IL2, IFN-γ, CXCR-5, CCR-5 and CD25 gene transcription. CSA decreased the density of CD69 on T-cells but did not interfere...
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