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Background The number of reported examples of chromatin architecture alterations involved in the regulation of gene transcription and in disease is increasing. However, no genome-wide testing has been performed to assess the abundance of these events and their importance relative to other factors affecting genome regulation. This is particularly interesting given that a vast majority of genetic variations...
DNA methylation plays an essential role in the regulation of gene transcription. Recent findings suggest that aberrant DNA methylation is closely related to carcinogenesis and cancer progression. Using publicly available data, genome-wide DNA methylation analysis of tumor and corresponding normal tissues was performed in multiple cancers. 114 varied-in-tumor CpG sites were commonly found in all the...
Functional genomics strategies have been slow to penetrate research on human stress and coping, but recent conceptual advances have yielded a raft of new findings relating social and psychological conditions to broad alterations in human gene expression. This article reviews the field of human stress genomics, analyzes some of the conceptual and technical issues that initially hampered its progress,...
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