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Background
The internal anal sphincter (IAS) exhibits slow waves (SWs) and tone that are dependent upon L‐type Ca2+ channels (CavL) suggesting that phasic events (ie, SWs) play a fundamental role in tone generation. The present study further examined phasic activity in the IAS by measuring the spatiotemporal properties of Ca2+ transients (CTs) in IAS smooth muscle cells (SMCs).
Methods
Ca2+ transients...
Background Intramuscular interstitial cells of Cajal (ICC‐IM) have been shown to participate in nitrergic neuromuscular transmission (NMT) in various regions of the gastrointestinal (GI) tract, but their role in the internal anal sphincter (IAS) is still uncertain. Contractile studies of the IAS in the W/Wv mouse (a model in which ICC‐IM numbers are markedly reduced) have reported that nitrergic...
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