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Objective
The P2X7 receptor (P2X7R) is an important contributor to neuroinflammation, responding to extracellularly released adenosine triphosphate. Expression of the P2X7R is increased in the brain in experimental and human epilepsy, and genetic or pharmacologic targeting of the receptor can reduce seizure frequency and severity in preclinical models. Experimentally induced seizures also increase...
Making the correct diagnosis of epilepsy is important as there are many mimics, some of which are life threatening. A good history, including an eyewitness account, is crucial as investigations may be unhelpful. Once a positive diagnosis is made, management requires attention to provoking factors or underlying disease together with antiepileptic drugs (AEDs). Thoughtful prescribing is required as...
Emergency situations require a rapid and precise diagnostic approach. However, the exact role and value of the electroencephalogram (EEG) in emergent conditions have yet to be clearly defined. Our objective was to determine why clinicians order an emergency EEG, to assess to what extent it helps establish a correct diagnosis and to evaluate the result it has on subsequent patient management.We studied...
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