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This paper present results of a multi-disciplinary project that is developing a microchip-based neural prosthesis for the hippocampus, a region of the brain responsible for the formation of long-term memories. Damage to the hippocampus is frequently associated with epilepsy, stroke, and dementia (Alzheimer's disease) and is considered to underlie the memory deficits related to these neurological conditions...
Recent physiological evidence has suggested that initiation of partial epileptic seizures may be due to a desynchronization rather than hypersynchronization of neuronal communication at a seizure focus. This hypothesis was tested using a computational model of the hippocampal slice possessing a physiologically-consistent network structure and behavior. When desynchronization was simulated using either...
We examined the effects of both intrinsic neuronal membrane properties and network parameters on oscillatory activity in a model of neocortex. A scalable network model with six different cell types was built with the pGENESIS neural simulator. The neocortical network consisted of two types of pyramidal cells and four types of inhibitory interneurons. All cell types contained both fast sodium and delayed...
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