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Blood coagulation plays an important part in a healthy haematological system. As part of the coagulation process, fibrin networks are formed from the circulating plasma proteins, called fibrinogen, forming a blood clot. During inflammation, the healthy clotting process is changed, and is translated to hypercoagulation, which is a hallmark of all inflammatory conditions. Hypercoagulation impacts directly...
A multiscale model of blood clot (thrombus) formation is extended by adding a sub-model of the tissue factor (TF) pathway of blood coagulation to provide more biologically relevant description of coagulation process. A combination of experimental approach, image analysis and a multiscale modeling is used for studying role of factor VII and fibrin in limiting growth of a blood clot. The simulations...
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