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Introduction
Plasma‐derived FVIII/VWF complex was reported to be less sensitive to inhibitors than FVIII preparations devoid of VWF.
Aim
To compare the efficacy of FVIII/VWF complex (Fanhdi) and five different VWF‐free FVIII preparations in restoring thrombin generation and activation of thrombin‐activatable fibrinolysis inhibitor (TAFI) in haemophilic plasma, with and without inhibitor, and in...
Although the S3 pocket of the thrombin active site is lined with lipophilic amino acid residues, the accommodation of polarity within the lipophilic P3 moiety of small molecule inhibitors is possible provided that the polar functionality is capable of pointing away from the binding pocket outwards toward solvent while simultaneously allowing the lipophilic portion of the P3 ligand to interact with...
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