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The human use of electronic displays (television or computers), also known as “screen time,” is currently a topic of great interest within behavior medicine and general clinical research. This behavior has been linked with a wide variety of pathologies, including obesity, circadian disruption, sleeping disorders, cardiometabolic disease, and socio-emotional behavior disorders in children. As an alternative...
Operator tiredness and fatigue pose significant safety risks in industries such as mining, trucking, aviation and air traffic control. Fatigue is a major factor behind on-the-job accidents, absenteeism and lowered productivity. The detection and prediction of fatigue is a technical challenge, confounded by the practical constraints of the working environment. This paper presents a mathematical fatigue...
In the mammalian circadian clock located in the suprachiasmatic nucleus (SCN) glutamate mimics light-induced phase shifts through activating NMDA receptors (NMDAR). These phase shifts require concurrent activation of TrkB receptors by brain-derived neurotrophic factor (BDNF). tPA contributes to phase shifting by influencing mBDNF generation. tPA also binds to receptors, including LRP-1 and may modulate...
Alcohol abuse leads to cognitive defects, depression, and sleep disturbances. The connection between sleep and circadian disruptions led us to investigate ethanol's effect on the circadian clock. We demonstrated that acute ethanol blocks photic phase shifts in vivo and glutamatergic phase shifts in vitro. Ethanol exposure can lead to acute, rapid and/or chronic tolerance. We determined that the suprachiasmatic...
Circadian regulatory system is an evolutionarily ancient biological system. Its prevalence in life kingdoms suggests it has fundamental role in life processes. Although genomic scale of circadian gene expression has been found in various species from cyanobacteria to mammalians, transcriptional patterns and mechanisms of global circadian gene regulation have not yet been revealed. Using high resolution...
Heart rate variability (HRV) markers have been widely used to characterize the autonomous regulation state of the heart from 24-h Holter monitoring, but long-term evolution of HRV indexes is mostly unknown. A dataset of 7-day Holter recordings of 22 patients with congestive heart failure was studied. A rhythmometric procedure was designed to characterize the infradian, circadian, and ultradian components...
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