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To explore the impact of dose intensity (DI) in the adjuvant setting of breast cancer, a randomized phase III trial was conducted comparing postoperative dose-dense sequential chemotherapy with epirubicin, paclitaxel, and cyclophosphamide, methotrexate and fluorouracil (CMF)in high-risk breast cancer patients. From Oct 2000 to June 2005, 1,121 node-positive patients were randomized to dose-dense sequential...
The overall survival improvement by adjuvant chemotherapy is partly related to patient age, stage and chemotherapy regimens used. Too low dose dose-intensities or total doses will result in inferior outcomes. Conventional dose escalations above standard doses will not be beneficial for doxorubicin or cyclophosphamide, while an epirubicin dose of 90-100mg/m 2 given every third week in polychemotherapy...
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