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PurposeDynamic susceptibility contrast (DSC) perfusion images are contaminated by contributions from macro vascular signal arising from contrast agent within the larger arteries that do not contribute directly to the local tissue perfusion.
MethodsA vascular model of the DSC perfusion signal was extended by the inclusion of a macro vascular component based on the arterial input function. This was...
Perfusion weighted MRI has proven very useful for deriving hemodynamic parameters such as CBF, CBV and MTT. These quantities are important diagnostically, e.g. in acute stroke, where they are used to delineate ischemic regions. Yet the standard method for estimating CBF based on singular value decomposition (SVD) has been demonstrated to underestimate (especially high) flow components and to be sensitive...
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