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We introduce a novel unifying approach to jointly estimate the motion and the dynamic images in first pass cardiac perfusion MR imaging. We formulate the recovery as an energy minimization scheme using a unified objective function that combines data consistency, spatial smoothness, motion and contrast dynamics penalties. We introduce a variable splitting strategy to simplify the objective function...
We recently proposed an accelerated dynamic magnetic resonance imaging (MRI) reconstruction algorithm that exploits the underlying low rank and sparse properties of the data to achieve highly accelerated reconstructions. In this paper, we validate our algorithm in the context of dynamic free breathing cardiac Perfusion MRI on the Physiologically Improved Non Uniform Cardiac Torso Phantom, PINCAT phantom...
We developed a method for automated quantification of myocardial perfusion from cardiac magnetic resonance (CMR) images. Our approach uses region-based and edge-based level set techniques for endocardial and epicardial border detection combined with non-rigid registration achieved by a 2D multi-scale cross-correlation and contour adaptation. This method was tested on 66 short-axis image sequences...
Patient-specific correlation of perfusion defects and coronary arteries responsible for blood supply in the affected territories has the potential to improve accuracy of diagnosis and intervention planning, but cardiac cycle phase difference between perfusion and angiography datasets precludes the use of standard methods of 2D/3D registration. This paper presents a work-flow for mediated spatiotemporal...
Pulsed Arterial Spin Labeling (PASL) techniques potentially allow the absolute, non-invasive quantification of brain perfusion and arterial transit time. This can be achieved by fitting a kinetic model to the data acquired at a number of inversion time points (TI). The intrinsically low SNR of PASL data, together with the uncertainty in the model parameters, can hinder the estimation of the parameters...
The purpose of this study is to evaluate cardiac and respiratory modulations in the signals of arterial spin labeling (ASL) perfusion magnetic resonance imaging (MRI) using RETROICOR, an image domain based retrospective correction method. Systematic comparisons were conducted for tagging schemes, pulsed (PASL) versus frequency-modulated continuous (CASL) methods, and the use of background suppression...
Magnetic resonance imaging (MRI) provides high spatial resolution, temporal resolution, and tissue contrast. It is ideally suited for the noninvasive assessment of cardiac structure and function. For routine cardiac patient management, functional assessment includes ventricular and valvular function, myocardial viability, perfusion, and metabolism. Highly desired but not yet available for managing...
The aim of the present study was to test the hypothesis that perfusion SPECT, estimation of regional wall thickening using MRI and the distribution of ST changes on the admission ECG display similar localization of the MaR in patients with reperfused first-time MI. Eleven patients with first-time MI with ST-elevation underwent percutaneous coronary intervention (PCI), SPECT imaging within 3 hours...
Cardiovascular magnetic resonance has been shown to provide high data quality for myocardial perfusion assessment. However, to analyze the perfusion data, some signal processing and modeling is needed to correct for motion related artifacts and limited spatial resolution. This study describes a method based on system identification, allowing, after a first step of image registration, to integrate...
Cardiovascular MR imaging (CVMR) has become a valuable diagnostic imaging modality for the non-invasive detection cardiovascular diseases. In this review, first key concepts and practical considerations of parallel CVMR are outlined. Next, highly accelerated CVMR applications are reviewed, ranging from cardiac anatomical and functional assessment to myocardial perfusion and viability to MR angiography...
Cardiovascular MR imaging (CVMR) has become a valuable diagnostic imaging modality for the non-invasive detection cardiovascular diseases. In this review, first key concepts and practical considerations of parallel CVMR are outlined. Next, highly accelerated CVMR applications are reviewed, ranging from cardiac anatomical and functional assessment to myocardial perfusion and viability to MR angiography...
Steering micro-carriers being tracked by an MRI system may be very attractive in oncology. Here, iron oxide microparticles have been steered in a Y-shaped microchannel placed between a Maxwell pair (dB/dz=443 mT/m) located in the center of an MRI bore. A suspension of 10.82 mum iron oxide particles was injected into the channel and a magnetic gradient generated by the Maxwell pair was used to deflect...
Steering micro-carriers being tracked by an MRI system may be very attractive in oncology. Here, iron oxide microparticles have been steered in a Y-shaped microchannel placed between a Maxwell pair (dB/dz=443 mT/m) located in the center of an MRI bore. A suspension of 10.82 mum iron oxide particles was injected into the channel and a magnetic gradient generated by the Maxwell pair was used to deflect...
Evaluation of quantitative parameters such as regional myocardial blood flow (rMBF), blood volume (rMBV), and mean transit time (rMTT) by MRI is gaining acceptance for clinical applications, but still lacks robust post-processing methods for map generation. Pixel by pixel analysis leads to high variance of the estimates and variance reduction by posterior spatial averaging does not produce satisfactory...
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