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The paper describes the application of graph theoretic concepts to the dynamic cross-correlation data obtained from MD simulations of adenine riboswitch, in the absence and presence of adenine. This novel approach combines both community detection algorithms that support edge weights, and cliques. The effect of variations in the values of nearest neighbors (NN) and correlation coefficient threshold...
We present a mechanical analysis platform with microsecond time resolution and nanometer scale spatial resolution. This technology facilitates high throughput mechanical analysis of biomolecules for biosensor applications.
Micro- and nanofabrication has allowed the creation of ultra-sensitive, miniaturized, and inexpensive biosensors. These devices generally utilize chemical or biological receptors which recognize a particular compound of interest and transduce this recognition event into a measurable signal. Recent advances in RNA and DNA synthesis have enabled the use of aptamers, which are in-vitro generated oligonucleotides...
Extraction of a specific molecule from cells is one of the important issues for the muTAS. However, current microfluidic device technologies are not sufficient for extraction and purification of DNA, RNA and proteins from cells. We reported earlier a selective DNA trapping employing mutually reverse electric force and hydrodrag force field in a micro-fabricated taper-shaped channel. This technique...
We present a device for selective extraction, concentration and release of metabolic molecules using ribonucleic acid (RNA) aptamers. The device consists of microfabricated PDMS channels on a glass substrate including a micro-chamber packed with an aptamer stationary phase. Features include: extraction and preconcentration of trace amounts of adenosine monophosphate (model analyte); sufficiently low...
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