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Silcion field-effect transistor (SiNW FET) biosensors have recently been demonstrated experimentally for direct, label free, high sensitive, high selective and real time detection of DNA and proteins at very low concentration. Among these experiments, the detection of Biotin/Streptavidin binding is of special interest since the biotin/ Streptavidin system exhibits the strongest noncovalent biological...
Recent bio-technologies enable us to successfully discover the functional organization of a cell by simultaneously measuring the dynamic change of concentrations of thousands of bio-molecules after specific perturbation. Such available input-output data offer system identification great chances and meanwhile challenges to build mathematical models of the dynamic transcriptional control system, which...
We use the stochastic linearized Poisson-Boltzmann equation to model the fluctuations in nanowire field-effect biosensors due to changes in the orientation of the biomolecules. Different orientations of the biomolecules with respect to the sensor surface due to Brownian motion have different probabilities. The probabilities of the orientations are calculated from their electrostatic free energy. The...
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