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Silcion field-effect transistor (SiNW FET) biosensors have recently been demonstrated experimentally for direct, label free, high sensitive, high selective and real time detection of DNA and proteins at very low concentration. Among these experiments, the detection of Biotin/Streptavidin binding is of special interest since the biotin/ Streptavidin system exhibits the strongest noncovalent biological...
Biochemical computing attempts to process information with biomolecules and biological objects. In this work we review our results on analysis and optimization of single biochemical logic gates based on enzymatic reactions, and a network of three gates, for reduction of the "analog" noise buildup. For a single gate, optimization is achieved by analyzing the enzymatic reactions within a framework...
A sensitive immunosensor based on charge detection is developed for proteins. Its aim is to select and quantify low protein concentrations in a complex environment. This highly sensitive sensor is a SGFET (Suspended Gate Field Effect Transistor) whose gate is suspended at 500 nm high above the silicon channel and embedded in silicon nitride. This electrical insulation and the general design of the...
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