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Surface-Enhanced Raman scattering (SERS) are potentially important tools in the characterization of biomolecules such as amino acids, complicated peptides and proteins, and even tissues or living cells. Amino acids and small peptides contain different functional groups. Therefore, they are suitable for the investigations of the competitive-interactions of these functional groups with colloidal silver...
The paper is dedicated to a cantilever sensor design/fabrication optimization which is related to a no curved structure, before bimolecular functionalization and immobilization. The advantage of cantilever arrays is not only their small size but also their suitability for mass production, which permits economically realistic, disposable sensors. The simulations of the cantilever in the static mode...
In order to fabricate reliable field emitters, the mass analysis of emitter surface at atomic level is the fundamental requirement. The only qualified instrument for the evaluation of the emitter surface is the atom probe (AP).
How to capture biologically important conformational transitions from structures have been of key interest in computational biology. It is generally recognized that normal modes derived from structure-based potentials can well represent functional movements in lots of biomolecules. Recently normal mode analysis was successfully used in an iterative manner to explore protein conformational transition...
Micro- and nanofabrication has allowed the creation of ultra-sensitive, miniaturized, and inexpensive biosensors. These devices generally utilize chemical or biological receptors which recognize a particular compound of interest and transduce this recognition event into a measurable signal. Recent advances in RNA and DNA synthesis have enabled the use of aptamers, which are in-vitro generated oligonucleotides...
Presented application is based on the use of carbon nanotubes for biomolecular analysis using electrochemiluminescence (ECL) detection technique ([1]-[9]). ECL is the generation of light by electron transfer between species electrochemically generated. ECL research has led to the successful ultrasensitive analysis of biomolecules in solution and commercialisation of several generations of ECL analyzers,...
Discussed are enabling biophotonic technologies that provide in-vivo like information earlier in drug discovery. The development of resonant waveguide sensor based high-throughput screening platform and utilization for studying signaling in cells will be described.
We present a method for finding biologically meaningful patterns on metabolic pathways using the SUBDUE graph-based relational learning system. A huge amount of biological data that has been generated by long-term research encourages us to move our focus to a systems-level understanding of bio-systems. A biological network, containing various biomolecules and their relationships, is a fundamental...
Postgenomic biology is characterised by large and diverse datasets presenting many technical challenges in data handling, analysis and integration. Further, there are significant challenges in converting the data into biological knowledge to support model building and hypothesis generation. A basic strategy is to find structure in the data (clusters) representing the coordinated response of system...
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