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Actin filament, one type of cytoskeletons, plays a central role in mediating cellular in responses to mechanical loading. Many mechanorgulation studies are restricted to 2D models using isolated cells or monolayer cultures, even though it is know that cells behave differently in term of cell morphology, cell matrix adhesion composition and matrix mediated force transmission when they are in 3D configuration...
The Achilles tendon plays an important role in our daily activities and studies have shown that tendon properties, such as morphology and stiffness, are related to aging, activity levels and genders. A better understanding of its morphology and mechanical properties will provide guidance to health professionals on intervention recommendation. However, the majority of the existing studies investigated...
The aim of our study was to develop a 3D model for myocardial wall stress (MWS) evaluation and to test its ability to characterize left ventricular (LV) aging and the effect of aortic valve stenosis (AVS). We studied 65 subjects (45 controls and 20 with AVS) who had a cardiac magnetic resonance (CMR) exam and a measure of central pressures. 3D MWS evaluation combined systolic pressures and an LV geometrical...
Background: Fixed-bearing posterior-stabilized (PS) total knee arthroplasty (TKA) has been used in Asian countries for several years, but few studies have investigated differences in the kinematic properties of the patellar tendon after standard PS TKA as compared to high-flex PS TKA. Purpose: To quantify the in vitro three-dimensional (3D) kinematics of the patellar tendon during passive high flexion...
In this study, the feasibility of BiPlane strain imaging during controlled muscle contraction by means of electrical stimulation was examined. Two superficial muscles, the tibialis anterior and the biceps, were imaged using triggered BiPlane ultrasound. Raw frequency data were acquired at 100 Hz during induced muscle contraction. The responses, in terms of strain, to different electrical stimuli were...
Understanding the mechanisms of eye movement is difficult without a realistic biomechanical model. We present an efficient and robust computational framework for building subject-specific models of the orbit from magnetic resonance images (MRIs). We reconstruct three-dimensional geometric models of the major structures of the orbit (six extraocular muscles, orbital wall, optic nerve, and globe) by...
Four-dimensional (4D), or equivalently, 3D + time, analysis is useful for comprehensive assessment cardiac function, especially in the asymmetric left ventricle (LV) after myocardial infarction (MI). This paper presents a 4D-model-based method for ultrasound assessment of cardiac contractile function in mice. Echocardiographic image sequences were acquired at high frequency (30 MHz) from the hearts...
In this paper, we present an extension of a computationally efficient Kalman filter based tracking framework to allow simultaneous tracking of several deformable models in volumetric data. The models are coupled through shared transform nodes in a hierarchical structure to enforce common position, orientation and scaling, but are allowed to alter shape independently. Automatic tracking of the endo-...
Earlier studies of our group based on synthetic volumetric ultrasound data showed that automatic intensity-based spatio-temporal elastic registration of currently available three-dimensional (3D) volumetric ultrasound data sets should allow to measure the full myocardial motion, deformation and strain in three dimensions. This is a clear advantage over currently available ultrasound methods, which...
In this study, the first preliminary results are reported of a beagle study on valvular aortic stenosis using BiPlane strain imaging. A previously reported strain method was applied to BiPlane RF-data of the heart of four beagles. A window-level tracking algorithm was devised, using a neighbour-based regularization force and a weighting factor that is highly depended on the cross-correlation values...
Atrial fibrillation is caused by some excited cardiac myocardium re-stimulated by the recurrent impulse that made the left atrium contraction irregularly. The changes of cardiac patterns could be recorded by the CT scan of the multi-slices and multi-frame technology. The abnormal rhythmic wall motion can be analyzed between the systolic of atrium and diastolic of atrium. This study has developed a...
A new method of measuring joint angle using a combination of 3D accelerometers and reaction force sensors is presented. Muscle motion is a common source of error to all body-mounted sensors. The effect of skin artefact was minimized based on the estimation of muscle motion measured using a new reaction force sensor banded with human body segment. The force sensor was designed using pressure sensitive...
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