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In this work we present a new electromechanical cardiac myocyte model tailored to reproduce the electrical and force generating activities of human ventricular myocytes. The model was created by coupling two existing models: the ten Tusscher electrophysiology model and the Rice myofilament mechanics model. The parameters of the new model were adjusted in order to replicate the available experimental...
A change in activation sequence by means of pacing induces changes in action potential (AP) morphology and duration. These changes are caused by electrical remodeling of ionic membrane currents and are reflected in the T wave in the electrocardiogram (ECG). Also the calcium transient is affected, which leads to changes in cardiomechanics. By modeling the cardiac muscle as a single fiber, we investigated...
Alternation of normal action potential morphology in the myocardium is a condition with a beat-to-beat oscillation in the length of the electric wave which is linked through electromechanical coupling to the cardiac muscle contraction, and is believed to be the first manifestation of the onset of life threatening ventricular arrhythmias and sudden cardiac death. In this work, the effects of electrical...
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