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Yeast cells form a single mating projection when exposed to mating pheromone, a classic example of cell polarity. Prolonged treatment with pheromone or specific mutations results in alternative cell polarity behaviours. The authors performed mathematical modelling to investigate these unusual cell morphologies from the perspective of balancing spatial amplification (i.e. positive feedback that localises...
Cell tensegrity model has been widely accepted as a qualitative and recently quantitative method to describe the cellular mechanics. It is based on the fact the cell body is an inhomogeneous cytoskeleton based structure bounded by a soft membrane. Cell establishes force balance under certain structural arrangement through its focal adhesions and intercellular adhesions, under which the prestress is...
Cell signaling is one of the fundamental processes that control the cell fate. It modulates the cell shape and mechanics. To identify the dynamic signaling pathway in situ, we need tools that are capable of monitor the real-time elasticity and viscosity changes as well as structural rearrangements. Atomic Force Microscopy (AFM) has been demonstrated to be an effective instrument to visualize membrane...
In the present study, a single elastic beam model based on nonlocal elasticity theory is presented for free vibration analysis of microtubules. The small scale effect is taken into consideration using the Eringen's nonlocal elasticity theory in conjunction with the different types of beam model such as Euler-Bernoulli, Timoshenko, Levinson and Reddy. Numerical results are given to show the size effect...
In all eukaryotes, cytokinesis is a big deformation process that a mother cell is divided to two daughter cells. It is involved in many mechanical actions, such as active contraction of microfilament, viscous flow of cytoplasm and big deformation of cortical membrane. In order to attain a better understanding of the cytokinesis process and corroborate a mechanical mechanism, various theoretical models...
Proper functioning of the immune system depends on coordinated intercellular communication that occurs in the "immunological synapse". This is the contact area of cell-cell conjugates where information is transferred via segregated clusters of proteins. Vast experimental datasets on its assembly are available, and mathematical and computational modeling represent a useful tool to integrate...
In this study a three-dimensional discrete fibre model was developed to provide insights into the important structure-function relationship in skin tissue. A structural approach determines the macroscopic mechanical response of the tissue from its underlying structural components. A network of collagen fibres was embedded into a tissue block of tissue. A family of fibres with varying orientations...
Collagen fibers are prominent constituents of many soft tissues. The fibers are able to carry load along their fiber axis, and, therefore, their structural arrangement renders the mechanical behavior of biological tissue anisotropic. In some tissues, e.g., blood vessels, tendons and ligaments, the fibers form fiber bundles. Structure-based biomechanical models of soft tissues strongly rely on a clear...
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