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The ability of activated leukocytes to retract pseudopods in response to fluid shear stress may be a critical mechanism to downregulate inflammation and maintain stable circulation. By measuring earlier indicators of leukocyte activation such as L-selectin shedding and β2 integrin activation, which precede morphological changes, we have found that exposure to physiological levels of fluid shear stress...
This paper aims to investigate the reasonable and effective nutrition ways for high level middle-distance runners in university. Six women middle-distance runners were chosen as experimental subjects. They were randomly divided into 2 groups, the experiment and the control group. It took 80 days to conduct this experiment. In the process of experiment, the same training plans were performed in the...
This paper mainly studies the anti-fatigue function and the mechanism of Epimedium flavones. The changes of the relative laboratory parameters in exercise fatigue were observed and the mechanism of resisting exercise fatigue of Epimedium flavones was discussed by using loaded swimming experiment of mice. The main contents are as follows: (1) Studying the effects of Epimedium flavones on the body weight...
Endothelial progenitor cells (EPCs) are mobilized from bone marrow to peripheral blood, and contribute to angiogenesis in tissues. In the process EPCs are exposed to the shear stress generated by blood flow and tissue fluid flow. Our previous study showed that shear stress promotes differentiation of EPCs into mature endothelial cells. In this study we investigated whether EPCs differentiate into...
Deformation of a red blood cell (RBC) in a high-shear flow was investigated. The RBC was modeled as a closed shell membrane consisting of spring networks in the framework of the energy minimum concept. The simulation of RBC in a parallel shear flow showed deformation parameters of RBC were well agreed with experimental results. The simulation of RBC behavior in various flow fields demonstrated that...
The Human Genome is essentially complete, and yet the impact on how we understand physiological processes such as cellular force transduction has been minimal in part because of our inability to work from known sequence to structure, i.e. the Foldome. In order to specifically identify cytoskeletal proteins that change conformation or assembly in stressed versus static cells, in situ labeling of sterically-shielded...
We fabricated micro flow channel based on the collagen tunnel for in vitro BBB blood capillary model using collagen gel tunnel, PDMS and infrared laser. This flow channel system can add the influence of shear stress to EC and evaluate the permeability by continuous microfluidic flow during cultivation. This system is expected to become a novel tool for emulating in vivo permeability of drug candidates...
We consider a possibility for estimating EMG and force amplitude based on hemoglobin density. In experiments, subjects carried out isometric movements of three levels of force amplitude in order to measure EMG, force amplitude and hemoglobin density, and these relationships were investigated. We confirmed strong correlations between these measurements. From these relationships we propose two estimation...
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