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We postulated that atrial fibrillation (AF) induced electrical remodelling in electrically heterogeneous human atria facilitates chronic AF. A modern biophysically detailed mathematical model of human atrial action potential was modified to incorporate electrophysiological properties of different cell types present within the atria. The heterogeneous cell models were then further modified to incorporate...
Information regarding the propagation dynamics of intramural electrical wavefronts in the 3D volume of the ventricles is critical in gaining a better understanding of normal and pathological cardiac function. However, investigation into such phenomena using cardiac modelling has so far been impaired due to limitations in the structural details included in current cardiac computational models. Here,...
Remarkable differences in action potential properties between the Purkinje fibre and ventricular cells may lead to abnormalities in excitation conduction through the Purkinje-ventricular junction (PVJ) and arrhythmogenic behaviour. We develop a family of electrophysiologically detailed computer models for rabbit epicardial, midmyocardial and endocardial ventricular myocytes, as well as the rabbit...
Researchers in cardiac mechanics and electrophysiology develop computer models for analyzing complex experimental data. A key issue is model correctness: formally verifying that the model is performing as intended. We present an application of formal software engineering methods to an established electrophysiology model: the Beeler-Reuter (B-R) model of the mammalian ventricular myocyte. A formal...
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