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It has been suggested that developmental alcohol-induced brain damage is mediated through increases in oxidative stress. Current research suggests that antioxidant therapy may afford some level of protection against the toxicity of alcohol and alcoholic beverage in cellular and genomic levels. Seven day pregnant wistar rats were randomly divided into three groups: control, ethanol and vitamin E treated...
We have previously produced a robust model of ethanol addiction in rats using a high-fat, alcohol-containing diet. Substitution of carbohydrate for fat in this diet greatly ameliorated the deleterious effect of alcohol, particularly the accompanying fatty liver. In the present study, we examined the role of certain antioxidants when added to the addictive, high-fat, alcohol-containing diet. Antioxidants...
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