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This work evaluates intercalation of Nortriptyline (NT) and Venlafaxine (VFX) in an interlayer gallery of Na+-MMT (Montmorillonite), which was further compounded with Poly (L-Lactide) (PLLA) to form microcomposite spheres (MPs) for oral controlled drug delivery. The XRD patterns, thermal and spectroscopic analyses indicated intercalation of drugs into the MMT interlayer that was stabilized by electrostatic...
Background Nortriptyline and venlafaxine are commonly used antidepressants for treatment of depression in older patients. Both drugs are metabolized by the polymorphic cytochrome P450-2D6 (CYP2D6) enzyme and guidelines for dose adaptations based on the CYP2D6 genotype have been developed. The CYP2D6 Screening Among Elderly (CYSCE) trial is designed to address the potential health...
Scaini G, Maggi DD, De‐Nês BT, Gonçalves CL, Ferreira GK, Teodorak BP, Bez GD, Ferreira GC, Schuck PF, Quevedo J, Streck EL. Activity of mitochondrial respiratory chain is increased by chronic administration of antidepressants.
Objective: Depressive disorders, including major depression, are serious and disabling for affected patients. Although the neurobiological understanding of major depressive...
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