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The ultraviolet B (UVB) sunburn model was characterized with a comprehensive battery of quantitative sensory testing (QST). Primary hyperalgesia in UVB-irradiated skin and secondary hyperalgesia in adjacent nonirradiated skin were studied in 22 healthy subjects 24h after irradiation with UVB at 3-fold minimal erythema dose of a skin area 5cm in diameter at the thigh and compared to mirror-image contralateral...
Neuroimmune interactions are of known importance in the genesis and maintenance of inflammatory pain states. However, the immune response to tissue damage is likely to differ depending on whether or not the injury is accompanied by infection. Many clinically important inflammatory pain states involve a sterile tissue injury. However, existing animal models of cutaneous inflammatory pain use injuries...
Epithelial lipoxygenases of bovine cornea were investigated in organ culture models. Subcellular fractions of the epithelium were incubated with14C-labelled arachidonate and the metabolites were analysed. Bovine corneal epithelial cells contain 15-lipoxygenase type 2 and 12-lipoxygenases of the leukocyte and the platelet types. The 15-lipoxygenase activity was prominent in the cytosolic fraction....
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