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The whole-cell voltage-clamp technique was applied to isolated ventricular myocytes to investigate the effects of extracellular and intracellular zinc application on L-type Ca2+ channel currents (ICa). Extracellular zinc exposure at micromolar concentration induced a reversible (with washout of ZnCl2) reduction (30%) of ICa with no change in current-voltage relationship. On the other hand, an increase...
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