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Studies have shown that the steroid anaesthetic alphaxalone positively modulates γ-aminobutyric acid (GABA) receptors in vitro. It has also been reported that positive modulation of GABA A receptors in the rat spinal cord can produce antinociception in vivo. This present study looks at the interaction of an intraperitoneal injection (i.p.) of the steroid anaesthetic combination Saffan ...
The novel anti-epileptic, lamotrigine (LTG) has been shown to exhibit antinociceptive effects in the rat. In the present study, the effect of LTG on the electrically-evoked release of endogenous amino acids from rat isolated spinal dorsal horn slices with intact dorsal roots has been examined and compared with those of morphine in the same preparation. LTG (0.1-300 μM) inhibited the release of aspartate,...
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