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Since transforming growing factor‐β (TGF‐β)/Smad signaling inhibits chondrocyte maturation, endogenous negative regulators of TGF‐β signaling are likely also important regulators of the chondrocyte differentiation process. One such negative regulator, Ski, is an oncoprotein that is known to inhibit TGF‐β/Smad3 signaling via its interaction with phospho‐Smad3 and recruitment of histone deacetylases...
Disturbed fibroblast growth factor (Fgf) and transforming growth factor beta (Tgfβ) signaling lead to a variety of human skeletal disorders. To reveal the possible function and interaction of these signaling systems we have started to analyze the expression patterns of signaling factors, antagonists, receptors and transducers of these pathways in forelimbs of mouse embryos and compared them to the...
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