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1H NMR-based metabonomic method was used to investigate the biochemical variability in serum from rats treated by nephrotoxins. The toxic effect of the model toxins, sodium chromate (Na2CrO4, 20 mg/kg body mass), 2-bromoethanamine hydrobromide (BEA, 250 mg/kg body mass) and mercury II chloride (HgCl2, 1 mg/kg body mass), was evaluated by 1H NMR spectroscopy accompanied by principal components analysis...
Tamoxifen, the widely prescribed drug in the prevention and therapy of breast cancer, may cause side effects which may be influenced by gender. The present study was undertaken to investigate the impact of gender on tamoxifen-induced toxic and biochemical changes following oral administration of tamoxifen at high dose level of 20 mg/kg once daily for a 2-week period in both male and female rats. The...
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